Heparin is a polyanionic polysaccharide that blocks initiation by RNA polymerase by virtue of its binding to
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Heparin is a polyanionic polysaccharide that blocks initiation by RNA polymerase by virtue of its binding to double-stranded DNA. But heparin inhibits only when added before the onset of transcription, and not if added after transcription begins. Explain this difference.
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Biochemistry Concepts And Connections
ISBN: 9780134641621
2nd Edition
Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews
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