Stability of compounds in new drugs. Refer to the Pfizer Global Research and Development study (reported in
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Stability of compounds in new drugs. Refer to the Pfizer Global Research and Development study (reported in ACS Medicinal Chemistry Letters, Vol. 1, 2010) of the metabolic stability of drugs, Exercise 2.35 (p. 77). Recall that the stability of each of 416 drugs was measured by the fup/
fumic ratio.
a. In Exercise 2.35, you determined the proportion of fup/fumic ratios that fall above 1. Use this proportion to determine the percentile rank of 1.
b. In Exercise 2.35, you determined the proportion of fup/
fumic ratios that fall below .4. Use this proportion to determine the percentile rank of .4.
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