Rule of Three Suppose n trials of a binomial experiment result in no successes.

According to the Rule of Three, we have 95% confidence that the true population proportion has an upper bound of 3 n. (See “A Look at the Rule of Three,” by Jovanovic and Levy, American Statistician, Vol. 51, No. 2.)

a. If n independent trials result in no successes, why can’t we find confidence interval limits by using the methods described in this section?

b. If 20 patients are treated with a drug and there are no adverse reactions, what is the 95% upper bound for p, the proportion of all patients who experience adverse reactions to this drug?