To put the E. coli replication system on a human scale, let us imagine that the 20--diameter

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To put the E. coli replication system on a human scale, let us imagine that the 20-Å-diameter B-DNA was expanded to 1 m in diameter. If everything were proportionally expanded, then each DNA polymerase III holoenzyme would be about the size of a medium-sized truck. In such
an expanded system:

(a) How fast would each replisome be moving?

(b) How far would each replisome travel during a complete replication cycle?

(c) What would be the length of an Okazaki fragment?

(d) What would be the average distance a replisome would travel between each error it made? Provide your answers in km/hr and km.

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Fundamentals Of Biochemistry Life At The Molecular Level

ISBN: 9781118918401

5th Edition

Authors: Donald Voet, Judith G Voet, Charlotte W Pratt

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