Do you think that genetic factors influence the relationship between smoking and RCC based on the preceding data? Why or why not?

Cancer, Genetics

A caseˆ’control study was performed of renal-cell carcinoma (RCC) (kidney cancer) [25]. The purpose of the study was to look at environmental risk factors for RCC and to assess whether genetic factors modify the role of environmental risk factors. There were a total of 113 cases and 256 controls studied.

The participants were subdivided into €œslow acetylators€ and €œrapid acetylators€ according to the NAT2 genotype. The hypothesis was that slow acetylators might metabolize potentially toxic substances more slowly than rapid acetylators and show different relationships with environmental risk factors such as smoking. Table 10.41 presents data for slow acetylators according to the number of cigarettes smoked per day.

Table 10.41: Relationship between number of cigarettes smoked per day and RCC among slow acetylators

 

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No. of cigarettes smoked per day Controls Cases 69 27 19 1-20 19 31 >20 27 1 nack contains 20 cinarettes