What is the relative risk for AMD for the CC genotype compared with the TT genotype? Ophthalmology,

Question:

What is the relative risk for AMD for the CC genotype compared with the TT genotype?

Ophthalmology, Genetics

Age-related macular degeneration (AMD) is a common eye disease among the elderly that can lead to partial or total loss of vision. It is well known that smoking and excessive weight tend to be associated with higher incidence rates of AMD. More recently, however, several genes have been found to be associated with AMD as well. One gene that has been considered is the Y402H gene (RS 1061170). There are three genotypes for the Y402H gene€”TT, TC, and CC. The relationship between AMD and the Y402H genotype is as follows:

Table 5.8 Association between Y402H genotype and prevalence of AMD in a high-risk population

AMD = yes AMD = no Y402H TT (wild type) 380 119 527 TC 278 121 CC Total 1185 281