Which methodology do you think is more appropriate in Problem 12.33?

Endocrinology

A study was conducted [15] concerning the effect of calcium supplementation on bone loss among postmenopausal women. Women were randomized to (1) estrogen cream and calcium placebo (n = 15), (2) placebo estrogen cream and 2000 mg/day of calcium (n = 15), or (3) placebo estrogen cream and calcium placebo (n = 13). Subjects were seen every 3 months for a 2-year period. The rate of bone loss was computed for each woman and expressed as a percentage of the initial bone mass. The results are shown in Table 12.36.

Table 12.36 Mean (±1 sd) slope of total-body bone mass (percentage per year) in the three treatment groups

 

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Treatment group (2) Calcium (n= 15) (1) Estrogen (3) Placebo (n= 13) -3.98 t 1.63 (n=15) -0.43 t 1.60 -2.62 t 2.68