The Michaelis-Menten kinetics reaction is given by [E+S underset{k_{1}}{stackrel{k_{3}}{longrightarrow}} E S underset{k_{2}}{longrightarrow} E+P] The resulting system of
Question:
The Michaelis-Menten kinetics reaction is given by
\[E+S \underset{k_{1}}{\stackrel{k_{3}}{\longrightarrow}} E S \underset{k_{2}}{\longrightarrow} E+P\]
The resulting system of equations for the chemical concentrations is
\[\begin{align*} \frac{d[S]}{d t} & =-k_{1}[E][S]+k_{3}[E S] \\ \frac{d[E]}{d t} & =-k_{1}[E][S]+\left(k_{2}+k_{2}\right)[E S] \\ \frac{d[E S]}{d t} & =k_{1}[E][S]-\left(k_{2}+k_{2}\right)[E S] \\ \frac{d[P]}{d t} & =k_{3}[E S] \tag{4.87} \end{align*}\]
In chemical kinetics, one seeks to determine the rate of product formation \(\left(v=d[P] / d t=k_{3}[E S]\right)\). Assuming that \([E S]\) is a constant, find \(v\) as a function of \([S]\) and the total enzyme concentration \(\left[E_{T}\right]=[E]+[E S]\). As a nonlinear dynamical system, what are the equilibrium points?
Step by Step Answer:
A Course In Mathematical Methods For Physicists
ISBN: 9781138442085
1st Edition
Authors: Russell L Herman