Eq. 27.53 shows the first step in the curved-arrow mechanism of peptide hydrolysis catalyzed by HIV protease. Complete the mechanism, using the two aspartic acid residues as catalytic groups.

Transcribed Image Text:

from an aspartic acid residue of the enzyme Pep E fo- R¹ E H O -NHCHC–NHCHC–NH–Pep R² from an aspartic acid residue of the enzyme -a water molecule in the active site (27.53)