When either Norvir or Crixivan bind to the active site of HIV protease, the OH group in
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When either Norvir or Crixivan bind to the active site of HIV protease, the —OH group in the middle of each molecule is found by X-ray crystallography to displace the tightly bound water present in the free enzyme. (See Eq. 27.53) Show how the two aspartic acid residues of the enzyme could interact with this hydroxy group in such a way that binding of the inhibitor is enhanced.
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The two Asp residues would be expect to interact wit...View the full answer
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