Nicotine, a habit-forming compound found in tobacco, can be protonated twice: (a) Using intuition gained from this

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Nicotine, a habit-forming compound found in tobacco, can be protonated twice:N CH3 B nicotine Ho HO H CH3 BH pK = 8.02 HO HO N H H CH3 BH pK= 3.13

(a) Using intuition gained from this section, and using the pKa values shown above, sketch on the same set of axes, without performing any calculations, plots of fB, fBH, and fBH2 over the pH range 1 to 10.

(b) At what pH do you think fBH is a maximum? Explain.

(c) What form of nicotine is present in greatest amount if a small amount of nicotine is dissolved in blood?

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Organic Chemistry

ISBN: 9781936221349

6th Edition

Authors: Marc Loudon, Jim Parise

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