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1. Compartment Model: This model is used for oral drug administration. Here we assume the drug is taken all at once orally and goes directly
1. Compartment Model: This model is used for oral drug administration. Here we assume the drug is taken all at once orally and goes directly to the stomach. The rate of adsorption from the stomach onto the central compartment ir Tars k,Co where k is the adsorption constant and Co is the concentration in the stomach. We also need to add a balance on the drug concentration in the stomach dC dt The initial concentration of the drug in the stomach is taken to be 40 micrograms per mL For the three compartment model, we have the differential equations for the Central, Peripheral and the Oral compartment as: dC dt dC as.2 =-krof, + ka.cc dt dC dt If ke 2.0 kr 3.0 kcp 1.0 kpc = 1.0 ka- 4.0 solve the equarions and found the profile of concentrations with matlab, expres the matlab code CcConcentration of drug in Central Compartment Cp-Concentration of drug in Peripheral Compartment Co Concentration of drug in Oral Compartment Identify clearly with its name each concentration in the matlab graphic
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