10. A key aspect of pharmaceutical design is the determination of bioavailability, the ability of a potential pharmaceutical agent (drug molecule) to be distributed throughout the body. One aspect of bioavailability is solubility: A drug molecule must be sufficiently soluble in water (hydrophilic) so that it can be distributed throughout the body in the bloodstream, but it should be also sufficiently hydrophobic so that it can move across cell membranes. To address this issue early in the drug development process, tests are conducted to observe a potential drug molecule's relative solubility in water and the molecule's relative hydrophobicity is assessed using octanol as a representative nonpolar solvent. Based on your understanding of solubility, rank these potential drug molecules from least soluble in water to most soluble in water. Electronegativity values are 2.1,2.5,2.8,3.0, and 3.5 for H,C,Br,N, and O, respectively. Justify your rankings