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2. Reaction scheme shown below is the mechanism for the formation of compound N from compound 1 using Pd(II)-catalyzed coupling reaction. Draw the structure of
2. Reaction scheme shown below is the mechanism for the formation of compound N from compound 1 using Pd(II)-catalyzed coupling reaction. Draw the structure of the missing intermediate K, L and M. [6 marks) intramolecular intramolecular Pd (dba), CHCI Ph3P, ACOH PhH, 53 C [K] cartopakociation (L) carbopeladation [M] OTBS 1 B-hydride elimination OTBS N 3. Provide the missing intermediates of P, Q, and R in the mechanism for the formation of compound O in the reaction scheme shown below. [9 marks) H Pd(OAC), 10 mol % Php, 20 mol % Ag2CO3, THF, 65C OTBS H O oxidative addition OTBS 1,2-insertion 1,2-insertion [P] B-hydride elimination (R) 4. Write a complete mechanism for the formation of compound S shown below. (5 marks] OTBS -OTBS Pd(OAC)2 (3 mol %) cydohexane, (R)-BINAP Ag2CO3, 40C 1-methyl-2-pyrrolidine S 2. Reaction scheme shown below is the mechanism for the formation of compound N from compound 1 using Pd(II)-catalyzed coupling reaction. Draw the structure of the missing intermediate K, L and M. [6 marks) intramolecular intramolecular Pd (dba), CHCI Ph3P, ACOH PhH, 53 C [K] cartopakociation (L) carbopeladation [M] OTBS 1 B-hydride elimination OTBS N 3. Provide the missing intermediates of P, Q, and R in the mechanism for the formation of compound O in the reaction scheme shown below. [9 marks) H Pd(OAC), 10 mol % Php, 20 mol % Ag2CO3, THF, 65C OTBS H O oxidative addition OTBS 1,2-insertion 1,2-insertion [P] B-hydride elimination (R) 4. Write a complete mechanism for the formation of compound S shown below. (5 marks] OTBS -OTBS Pd(OAC)2 (3 mol %) cydohexane, (R)-BINAP Ag2CO3, 40C 1-methyl-2-pyrrolidine S
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