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4. Fill in the table below with 1 2, or 3 as appropriate to rank the expected hydrophilicity of each of the illustrated molecules under

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4. Fill in the table below with "1" "2", or "3" as appropriate to rank the expected hydrophilicity of each of the illustrated molecules under the given conditions, with 1 being the most hydrophilic and 3 being the least hydrophilic. If any compound is expected to be hydrophobic under all conditions, write that in every box in that row. If any compound is expected to be hydrophilic under all conditions, write that in every box in that row. Lastly. justify your responses in every case with a brief and specific rationale Molecule pH 2 pH 7 PH 13 .. ar CH 5. Two druglike molecules are shown below in their uncharged state. Given the pk, values discussed in lecture, re- draw the molecules in the lonization state you would expect them to exhibit under the given conditions/prevailing pH. No explanation is necessary. OH -H HO HS N , (in blood) NH2 NC (in small intestine)

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