Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

5. Cells bind to extracellular matrix (ECM) proteins via membrane receptors called integrins. The integrin-ECM bond is usually under some tension, as the cell pulls

image text in transcribed

5. Cells bind to extracellular matrix (ECM) proteins via membrane receptors called integrins. The integrin-ECM bond is usually under some tension, as the cell "pulls" on the ECM. As we know from problems \#1-4, exerting a force on a molecule causes a change in the molecule's partition function. A) If the partition functions of the integrin and ECM are ZINT(x,T) and ZECM(x,T), respectively, where x is the location of the integrin-ECM bond, what is the partition function Z(x,T) of the entire integrin-ECM system? The integrin-ECM bond energy is (a positive value, by convention). B) Show that (xlnZINT)T=(xlnZECM)T at equilibrium, and interpret this expression in terms of a balance of forces. C) Show that if is too small, the integrin-ECM bond is not stable, i.e., it is likely to rupture

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Introduction To Chemical Engineering Tools For Today And Tomorrow

Authors: Kenneth A. Solen, John N. Harb

5th Edition

0470885726, 978-0470885727

More Books

Students also viewed these Chemical Engineering questions