5. Steps involved in the synthesis of Oxazepam from 6-chloro-2-xhloromethyl-4-
phenylquinazolin-3-oxide in the correct sequence is?
I. Polonovski reaction
II. Treatment with sodium hydroxide
III. Hydrolysis
a) I – II – III
b) I – III
c) II

d) II – I – III

6. The drug Oxazepam is mainly used for?
a) Treatment of anxiety
b) Treatment of Acute alcohol withdrawl
c) Both a) and b)
d) Constipation

7. Which of the following drugs is a volatile substance that is administered by inhalation?
(a) Thiopental
(b) Halothane
(c) Alprazolam
(d) Buspirone

8.The brief duration of action of an ultra-short acting barbiturate is due to a
(a) Slow rate of metabolism in the liver
(b) Low lipid solubility, resulting in a minimal concentration in the brain
(c) High degree of binding to plasma proteins
(d) Slow rate of excretion by the kidneys

9. Which of the following mechanisms of action most likely contributes to the treatment of
parkinsonism?
(a) The direct-acting dopaminergic agonist amantadine mimics the activity of striatal dopamine
(b) The antimuscarinic activity of dophen-hydramine contributes to the restoration of striatal
dopaminergic-cholinergic neuro-transmitter balance
(c) Striatal H1 – receptors are blocked by the antihistaminic trihexyphenidyl
(d) The ergoline bromocriptine stimulates the release of striatal dopamine from intact terminals.

10. All of the following adverse effects areassociated with the use of levodopa except
(a) Orthostatic hypotension
(b) Delusions, confusion, and depression
(c) Dyskinesia and dystonia
(d) Livedo reticularis