6. A woman seeks genetic counselling as she wants to know the likelihood of passing on haemophilia to her children . Her parents let her know that there are a few cases of the disorder in the family 's history Both of her F8 gene copies are sequenced . One is wild -type , while the other has a substitution at base -pair 6 of the coding sequence : G-C to A-T. i. Determine the effect of the substitution on the protein sequence What type of mutation would this be (silent , missense , nonsense )? What should the genetic counsellor tell her ? ii. The woman's husband is phenotypically normal , ie shows no sign of haemophilia Should the couple be advised to also get his ONA checked for