Question: 7-) microRNAS (miRNAs) could be either up or down regulated in some types of cancers. Thus, a sensitive detection for miRNAS is of great

7-) microRNAS (miRNAs) could be either up or down regulated in some

7-) microRNAS (miRNAs) could be either up or down regulated in some types of cancers. Thus, a sensitive detection for miRNAS is of great importance in biomedical research. Synthetic microRNA oligonucleotides sequences (mir21, antimir21, mir192) are given below to design a novel electrochemical biosensor approach for direct detection of target miRNA as a cancer biomarker. (9 points) Please match them with (i) complementary (capture probe); (ii) non-complementary; (ii) target mir21 : 5'-UAG CUU AUC AGA CUG AUG UUG A-3' antimir21 : 5'-UCA ACA UCA GUC UGA UAA GCU A-3' -> mir192 : 5'-CUG ACC UAU GAA UUG ACA GCC-3'

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