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8) Lipophilicity (LogD) is a critical concept in drug discovery and is usually measured or calculated as a partition coefficient between octanol and water. In
8) Lipophilicity (LogD) is a critical concept in drug discovery and is usually measured or calculated as a partition coefficient between octanol and water. In class it was shown how structural changes and incorporation of various functional groups can impact the LogD of a compound. Shown below are six analogs of the keto-pyran derivative 1 where the R group has been substituted by a number of different functional groups as shown. Without worrying about specific LogD values, rank order analogs A through G from lowest LogD to highest LogD. Fill in your answers below
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