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A new antibiotic drug was given in a single intravenous bolus of 4mg/Kg to five healthy male adults ranging in age from 23 to 38

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A new antibiotic drug was given in a single intravenous bolus of 4mg/Kg to five healthy male adults ranging in age from 23 to 38 years (average weight 75Kg ). The plasma level-time curve for this drug fits a one-compartment model. The equation of the curve that best fits the data is Cp=78e0.46t Determine the following (assume units of micrograms per milliliter for Cp and hours for t : a. What is the t1/2 and Vd ? b. What is the plasma level of the drug after 4hr and How much drug is left in body after 4hr ? c. Predict what body water compartment this drug might occupy and explain why you made this prediction. d. Assuming the drug is no longer effective when levels decline to less than 2 ug/ml. when would you administer the next dose? (8 Marks)

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