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A study was done to compare Inhaled Nitric Oxide versus Inhaled Epoprostenol for Acute Pulmonic Hypertension following Surgery. Method: Single-center retrospective, observational cohort study comparing

A study was done to compare Inhaled Nitric Oxide versus Inhaled Epoprostenol for Acute Pulmonic Hypertension following Surgery.

Method: Single-center retrospective, observational cohort study comparing the two inhaled agents. The primary outcome was reduction of mean pulmonary artery pressure (mPAP) to < 30 mm Hg. 6 hours after ICU admission from the operating room. Secondary outcomes, included ICU and and hospital length of stay, duration of mechanical ventilation, bleeding complications, hypotension, in-hospital mortality, and cost.

McGinn, K., & Reichert, M. (2016). A comparison of Inhaled Epoprostenol for Acute Pulmonary Hypertension following cardiac surgery. Annals of Pharmocology, (50)1, 22-36. DOI: 10.1177/1060028015608865.

Question 1: Identify the specific variables being investigated. If applicable, identify the independent and dependent variable.

Question 2: Identify and critique the method used to measure each of the outcome variables. (They used comparisons between groups and analyzed using the X2 or Fischer's exact tests for categorical data. Continuous data were reported as means and medians and compared using the Student t test or Mann-Whitney U test. P value<0.05.

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