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analyze and estimate the pKa of each numbered proton. Once you have analyzed each proton through providing proper structural evidence and annotations to support your

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analyze and estimate the pKa of each numbered proton. Once you have analyzed each proton through providing proper structural evidence and annotations to support your analysis, evaluate your estimated pka's to rank them in order of increasing acidity. To help your reasoning, you may draw truncated drawings by replacing the parts of the molecule that don't affect the acidity of a particular proton and defining them the truncated portion as R,R,R etc. "Note there may be competing effects for a particular proton, those that increase acidity while others decrease acidity. When in doubt draw it out. Be as detailed as possible. analyze and estimate the pKa of each numbered proton. Once you have analyzed each proton through providing proper structural evidence and annotations to support your analysis, evaluate your estimated pka's to rank them in order of increasing acidity. To help your reasoning, you may draw truncated drawings by replacing the parts of the molecule that don't affect the acidity of a particular proton and defining them the truncated portion as R,R,R etc. "Note there may be competing effects for a particular proton, those that increase acidity while others decrease acidity. When in doubt draw it out. Be as detailed as possible

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