Answers should be about.... Q1: 150mg QD; Q2: 61mg/L; Q3: 5 days. Please show work.

Population parameters for phenobarbital are: F=1.0;fe=0.24;fu=0.5;CL=0.1L/kg/ day; V=0.65L/kg;TI is 10 30mg/L Q1: Design a dosing regimen for Mr. HJ a 5'11", 232 lbs, 47-year-old patient. Three months after the start of the regimen, Mr. HJ was brought into the emergency room after having taken a total of 25 tablets (100 mg strength) in an attempted suicide. Q2: What plasma level would you anticipate Mr. HJ to have of phenobarbital on arrival in the ER room? Q3: How long will it take before plasma concentrations reach therapeutic levels if no more phenobarbital was given