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Compare Atropine (basic drug, pKa = 9.9) and Penicillin G (acidic drug, pKa = 2.8) solubility in gastrointestinal tract. Calculate % drug ionization in stomach

Compare Atropine (basic drug, pKa = 9.9) and Penicillin G (acidic drug, pKa = 2.8) solubility in gastrointestinal tract. Calculate % drug ionization in stomach (pH =2.0) and in intestine (pH =8.0). Which drug will be mainly absorbed in the stomach? In the intestine? In which case the highest bioavailability will be achieved?

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