Compose an 18-page course paper addressing the theme of "tobacco regulation, encompassing advertising and promotion," incorporating discussions of violations experienced by three significant pharmaceutical entities. Give particular emphasis to a cohesive synopsis of these violations within the paper's sections, including the Introduction, Understanding Tobacco Regulation with its advertising and promotional aspects, Definition and Statistics within the USA, Advantages and Disadvantages of Tobacco Regulation, as well as an exploration of the Current Legal, Regulatory, and Guideline Frameworks governing tobacco, encompassing its advertising and promotion. Conclude by summarizing key insights and proposing future directions.