Enzyme is immobilized in spherical beads. Substrate diffuses from the surface to the center of the beads. a) Assuming substrate concentration is relatively small compared to enzyme Km. Derive an expression of the effectiveness factor as a function of Thiele modulus φ. b) Assuming Km is relatively small compared to substrate concentration. Derive an expression of the effectiveness factor as a function of radius (R) of the spherical beads, Ss, D, and Vm