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(f) A feed stream of powder containing lactose filler and salicylic acid (API) in the required ratio will be sent to a granulator. A

 

(f) A feed stream of powder containing lactose filler and salicylic acid (API) in the required ratio will be sent to a granulator. A common liquid binder, povidone, will be added to the mixture via an additional stream. The composition of the product stream exiting the unit must be 5 wt% API, 80 wt% filler, and 15 wt% liquid binder. If 6000 tablets/h are required, with each tablet containing 180 mg of API, calculate the flow rates needed for all three streams (in kg/h). You may use this flowchart: m; (kg/h) Feed min, (kg/h) Granulator Product 0.80 kg Filler/kg 0.05 kg API/kg m2 (kg/h) 0.15 kg Binder/kg Pure Binder

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