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Flufenamic acid (FFA) is an analgesic and non-steroidal anti-inflammatory agent that is used in some countries to relieve the pain associated with meumatoid arthinis. The
Flufenamic acid (FFA) is an analgesic and non-steroidal anti-inflammatory agent that is used in some countries to relieve the pain associated with meumatoid arthinis. The chemical stucture for the acid form of Flufenamic acid is shown below. (a) Draw the structure of the conjugate base of Flufenamic acid. (1 mark) Shown below ts the speclation of Flufenamic acld as a function of pH. (b) What is the pKa for Flufenamic acid? Justify your answer. (2 marks) (c) The pH of the stomach is 1.5. What is the ratio of acid to base in the stomach? (1 mark) (d) The pH of the small intestine is 7.5. Would flufenamic acid be absorbed more readily from the stomach or small intestine? Explain your answer, making reference to the speciation. (3 marks) Amach Fie
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