Genome mining is an emerging approach to drug discovery. 

i. Genome mining involves a combination of genomics, bioinformatics, molecular biology, and analytical chemistry. Briefly outline what takes place at each of these steps in the process.

ii. What are the general features of a pleiotropic approach to activating a silent biosynthetic gene cluster (BGC)? Briefly outline the main advantage and the main disadvantage of such approaches. Give one example of a pleiotropic approach that can be used to activate silent BGCs.