In a 2² factorial experiment, the ANOVA results show that both factors are significant, as well as the interaction effect. The factor A main effect is 20, and the factor B main effect is -10. A regression analysis is performed using the following regression equation, where the terms x₁,x₂ and correspond to factor A, factor B and their two-way interaction, respectively. Estimate the value of beta_1 in the equation.

Y = Bo + B1x1+ 32x2+ 12x1X2 + 6