In a defined population, the major histocompatibility complex (MHC) haplotype HLA-DQB12*0302 is present in 30% of individuals. When carrying out a study on 60 patients with type 1 diabetes mellitus from this population, it is found that 30 of them have HLA-DQB12*0302.

Using a manually calculated -test, determine whether there is any evidence that the HLA-DQB12*0302 allele is associated with susceptibility to type 1 diabetes based upon these data. In your answer, you should present the following:

a.A data table based upon Table1. Use the values to calculate your -value.

DQB12*0302	Observed	Expected	Obs-Exp	(Obs-Exp)2	(Obs-Exp)2/Exp
Present
Absent

b.The number of degrees of freedom and how you derived this.

c.The P-value, based upon the values found in Table2, that any association has occurred by chance.

Degrees of freedom	Probability
0.9	0.5	0.1	0.05	0.01
1	0.02	0.46	2.71	3.84	6.64
2	0.21	1.39	4.61	5.99	9.21
3	0.58	2.37	6.25	7.82	11.35
4	1.06	3.36	7.78	9.49	13.28
5	1.61	4.35	9.24	11.07	15.09

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