Question
In a phase III clinical trial, we would like to compare a new treatment with equal allocation. Let 1 and 0 be the population response
In a phase III clinical trial, we would like to compare a new treatment with equal allocation. Let 1 and 0 be the population response rates for the treatment and the control group, respectively. We want to test H0 : 1 0 = 0 vs. HA : 1 0 = 0 at a level = 0.05. We assume that we would like to have power 0.9 to detect 0 = 0.8 and 1 = 0.9. (a) If you were to use the proportions test to test for significance, based on the design considerations above, what sample size would you recommend? Please show all your calculations. (b) If you were to use the test based on the arc sine square root transformation to test for significance, based on the design considerations above, what sample size would you recommend? Please show all your calculations. (c) Please describe the type I error and type II error
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started