In clinical trials of a newly developed cold medicine, it was found that 45 out of 200 individuals that took the new medicine (Group 1) experienced an upset stomach as a side effect and 33 out of 150 individuals that took a placebo (Group 2) experienced an upset stomach. Test to see if the new drug produced a significantly higher proportion of individuals experiencing upset stomach. Use a 0.01 level of significance.

Select the correct alternative hypothesis and decision.