Isotretinoin is a drug that is used as a treatment plan in preventing, and stopping, severe acne that can not be treated with antibiotics. For this question, I need to know more about Isotretinoin, and for somebody to explain to me the following: 1) How does the drug work chemically? I understand it is used to decrease the size of the sebaceous glands in the skin, these glands are responsible for creating sebum, which is an oil in the skin that clogs pores and causes acne. However, I need to better understand how the actual drug works when swallowed, how does it attach itself? How does it bind? I need a breakdown on how it actually works once inside the body? And finally, how does it discrete itself out of the body. This is related to how does Isotretinoin find itself in the semen of male patients which is related to the side-effects known with this drug. 2) Why does this drug cause side-effects related to birth-defects, pre-mature births, and finally death of the child before birth? I need somebody to fully explain to me why this occurs, more focused on a chemical basis. What in this drug leads to it causing birth-defects, and how does that happen? Same goes for pre-mature births, and the death of the child before birth. If you answer these two questions in detail, actually explaining each step to me and why it occurs, I will one-hundred percent upvote your answer, leave positive feedback on that answer, and anything else that you ask to help you get more money and better feedback. Thank you!