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Must use Tables (no long wording allowed when a Table can do the job) so that I can read in 10 SECONDS. 3.1 3
Must use Tables (no long wording allowed when a Table can do the job) so that I can read in 10 SECONDS. 3.1 3 points. Fill in Carr Index and Flowability. Show how did you determined the Carr Index and flowability. Carr Index (CI) can be determined using the formula: CIE(Bulk DensityBulk Density-Tapped Density)100 Fill in Carr Index Rp1 Rp2 Rp3 Rp4 Rp5 Flowability % of oxycodone dissolved Dissolution Profiles are shown here. (Dissolution curves for entire design of 7 formulations are available). Rp1, Rp2 and Rp3 are shown for this exam. 1. Rp1 Formula: % of oxycodone dissolved 100 80 60 40 40 20 0 0 3 6 2. RP2 Formula: 100 80 60 40 20 0 3 6 B 9 9 Time (h) Time (h) pH1.2, 50rpm --pH1.2, 100rpm --PH1.2, 200rpm pH6.8, 50rpm pH6.8, 100rpm. pH6.8, 200rpm 12 15 18 pH1.2, 50rpm -PH1.2, 100rpm -pH1.2, 200rpm pH6.8, 50rpm. pH6.8, 100rpm pH6.8, 200rpm 12 15 18 % of oxycodone dissolved % of oxycodone dissolved 3. RP 3 Formula 100 80 60 40 20 C pH1.2, 50rpm -pH1.2, 100rpm -O-PH1.2, 200rpm pH6.8, 50rpm pH6.8, 100rpm pH6.8, 200rpm 0 0 36 9 12 Time (h) 15 18 4. Rp 3 Dissolution with and without Ethanol in stomach pH 100 pH1.2, 50rpm -pH1.2, 200rpm 80 60 40 20 pH1.2 with ethanol, 50rpm pH1.2 with ethanol, 200rpm 0 0 0.5 1 Time (h) 1.5 2
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