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Suppose you have bivariate data (x1, y1), . . . ,(xn, yn). A common model is that there is a linear relationship between x and y, so in principle the data should lie exactly along a line.

However since data has random noise and our model is probably not exact this will not be the case. What we can do is look for the line that best fits the data. Use a simple linear regression model.

For bivariate data the simple linear regression model assumes that the xi are not random but that for some values of the parameters a and b the value yi is drawn from the random variable

Yi axi + b + i where i is a normal random variable with mean 0 and variance 2. We assume all of the random variables i are independent.Prove the above.

Aging and population growth both contribute importantly to the rise in health care costs. However, the percentage contribution of these factors declined between 1970 and 1990, and we expect a continued decline through 2005. Data indicate that the relative costs of treating patients age sixty-five and over grew more rapidly than did the costs of treating other patients. Sensitivity analyses indicate that regardless of whether these trends persist, the percentage contribution of aging and demography is likely to decline between 1990 and 2005. Application of our model through 2030 suggests that if current trends persist, aging will cause a major acceleration in the rise in costs.

1.From the knowledge derived on protein amalgamation, determine the validity of the inference below and explain deeply.

Centered on charge, the SDS polyacrylamide gel electrophoresis classifies polypeptides. Identify a bond if any.

2.From the concept of executing with polypeptides, the _________ gel _________ and isoelectric _________ jointly form the mechanism of two-dimensional _________. What does it execute?

3.Why is it recommendable to incapacitate endogenous genes I organisms frequently?

4.What is produced by both individual organisms and methodical mutagenesis programs.

5.Within the discipline of genetic engineering, for __________ alteration, the focal code is __________ reunification to substitute the __________ chromosomal replica of a genetic material with the __________ gene.

6.Identify the impact of a selectable indicator in a scenario where the gene to be modified is replicated and a selectable indicator is interleaved? What should be the nature of the selectable indicator?

7.In which nature should the altered gene which is excised from the vector and introduced into the target organism be?

8.Validate the statement below.

Double crossover over the flanking sequence and their chromosomal complements triggers the indicator's incorporation into the chromosome to trigger steady attainment of the indicator.

9.Basing on data from genetics, provided ________ gene is present, then it is definite that double ________ may dispense ________ replica within the chromosome.

10.Certify the effect on the duplicate genes hosted in a target organism with more than one replica.