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PH 582: Epidemiology: Assignment 5 (100 points possible) The PREADViSE trial is a cooperative study to Selenium and Vitamin E Cancer Prevention Trial (SELECT) (a

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PH 582: Epidemiology: Assignment 5 (100 points possible) The PREADViSE trial is a cooperative study to Selenium and Vitamin E Cancer Prevention Trial (SELECT) (a large prostate cancer prevention trial) and was designed to evaluate the effectiveness of antioxidant supplements vitamin E and selenium in preventing incident AD and other forms of dementia in a randomized controlled trial (RCT). PREADViSE investigators remain blind to treatment assignment as of this writing, and so the effects of the antioxidant supplements will not be considered further here. During the recruiting period from 2002 to 2009, PREADViSE recruited 7,547 non- demented participants from 130 participating SELECT clinical sites in the US, Canada, and Puerto Rico. The general characteristics of the study subjects were summarized below. Provide one page of summary of the results in the table below and possible hypothesis you may create. Table 1. General characteristics of the study population in PREADViSE All Subjects No Sleep Apnea Sleep Apnea Characterlstlc (\"#715\") (n=6995) (\"=552) Missmg Baseline age, y 67.5153 67.6153 66.6145 1 (0.01) Education, y 15.0127 14.9127 15.1126 35 (0.46) Black race 756 (10.0) 685 (9.8) 71 (12.9) 0 (0.00) Baseline smoking 4260 (56.6) 3916 (56.1) 344 (62.4) 19 (0.25) APOE-E4 (21 4) 2,029 (26.9) 1876 (26.8) 153 (27.7) 0 (0.00) Baseline hypertension 2,998 (39.7) 2703 (38.6) 295 (53.4) 0 (0.00) Baseline diabetes 858 (11.4) 762 (10.9) 96 (17.4) 0 (0.00) Dementia 310 (4.11) 282 (4.0) 28 (5.1) 0 (0.00) Baseline BMI, k lm2 28514.4 28214.2 31.6-15.3 32 0.42

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