Phenytoin was administered to a patient at dosing rates of 150 mg/day and 300 mg/day respectively. The steady state plasma drug concentrations were 8.6 mg/L and 25.1 mg/L respectively. Based on this information if you determine the Km and Vmax of the patient to be 27 mg/L and 626 mg/day respectively, answer the following questions 1. What dose (mg) per day is needed to achieve a steady state concentration of 11.3 mg/L ? (consider both S and F as 1) 2. What would be the answer to the above question (dose in mg/day) if S of phenytoin is 0.93 and Fis 0.93? Your Answer Dose mg per day Dose mg per day