Question: Phosphoglucoisomerase (PGI) utilizes acid-base catalysis to interconvert glucose-6-phosphate and fructose-6-phosphate in the second step of glycolysis and penultimate step of gluconeogenesis. PGI a) To what

Phosphoglucoisomerase (PGI) utilizes acid-base catalysis to interconvert glucose-6-phosphate and fructose-6-phosphate in the second step of glycolysis and penultimate step of gluconeogenesis. PGI a) To what enzyme class does PGI belong? ( 5pts) b) PGI uses a histidine and a glutamate residue as acid-base catalysts during the catalytic cycle. Draw a single mechanism for the reversible PGI-catalyzed reaction. Indicate the flow of electrons for the forward (glycolytic) direction using solid arrows and that for the reverse (gluconeogenesis) direction using dashed arrows. (10 pts) c) What is the purpose of the PGI reaction in glycolysis? (5 pts) d) True or False: The overall Gibb's free energy change for the PGI reaction is highly exergonic. (5 pts)

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