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please answer all for thumps up:) Match the BLOSUM scoring matrix best suited for alignments of sequences from each pair of organisms. BLOSUM40 1. Dog
please answer all for thumps up:) Match the BLOSUM scoring matrix best suited for alignments of sequences from each pair of organisms. BLOSUM40 1. Dog to Wolf BLOSUM90 2. Dog to Frog 3. Dog to Yeast BLOSUM65 Most algorithms to find multiple sequence alignments use a "progressive alignment" strategy. What does this mean? Many multiple sequence alignments are supported by grant funding from Progressive Insurance. Sequences are aligned alphabetically: all "As" are aligned, then "Cs", then "Gs" and finally all "Ts" Columns in the alignment are merged with other columns until all sites are included. Subsets of the total data set are aligned and progressively merged into larger alignments until all sequences have been aligned If two the genomes of two species are described to have "high synteny", what does that mean? Their genomes have evidence of high rates of gene synthesis. Their genome alignment scored in top 5% of E-values. Their genomes have a high frequency of synthetic mutations. Their genomes have a similar order of genes on their chromosomes. Question 4 (5 points) What is an example of a bioinformatics problem for which almost all available tools attempt to find approximate solutions rather than exact solutions? Longest repeated substring Pairwise global alignment Multiple sequence alignment using the sum-of-pairs score Pairwise local alignment An E-value (Expect value) of 12 reported by BLAST means the following: You would still expect to find a match in the database even if you increased the size of the database 12 -fold. There are 12 query sequences that match the same sequence in the database. There is a one in 12 chance the sequence found in the database is similar to the query You would expect on average that 12 sequences like the query sequence would randomly match in the database Question 6 (5 points) BLAST uses global pairwise alignments to search databases for matches to a query sequence. True False Match the BLOSUM scoring matrix best suited for alignments of sequences from each pair of organisms. BLOSUM40 1. Dog to Wolf BLOSUM90 2. Dog to Frog 3. Dog to Yeast BLOSUM65 Most algorithms to find multiple sequence alignments use a "progressive alignment" strategy. What does this mean? Many multiple sequence alignments are supported by grant funding from Progressive Insurance. Sequences are aligned alphabetically: all "As" are aligned, then "Cs", then "Gs" and finally all "Ts" Columns in the alignment are merged with other columns until all sites are included. Subsets of the total data set are aligned and progressively merged into larger alignments until all sequences have been aligned If two the genomes of two species are described to have "high synteny", what does that mean? Their genomes have evidence of high rates of gene synthesis. Their genome alignment scored in top 5% of E-values. Their genomes have a high frequency of synthetic mutations. Their genomes have a similar order of genes on their chromosomes. Question 4 (5 points) What is an example of a bioinformatics problem for which almost all available tools attempt to find approximate solutions rather than exact solutions? Longest repeated substring Pairwise global alignment Multiple sequence alignment using the sum-of-pairs score Pairwise local alignment An E-value (Expect value) of 12 reported by BLAST means the following: You would still expect to find a match in the database even if you increased the size of the database 12 -fold. There are 12 query sequences that match the same sequence in the database. There is a one in 12 chance the sequence found in the database is similar to the query You would expect on average that 12 sequences like the query sequence would randomly match in the database Question 6 (5 points) BLAST uses global pairwise alignments to search databases for matches to a query sequence. True False
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