Please do this in R or jupyter notebook only to from 0 AL1A1 AL1A1 1 ITA7 ACHA 2 NEB1 ACTG 3 SRGN CD44 4 GRB7 ERBB2

a) Visualize the degree distribution of the network from a csv file whose head is above. Provide a plot and explain how would you characterize this distribution (e.g., normal, power-law, etc.). Provide another plot with a log-log scale and explain what can be achieved by displaying this plot on a log-log scale.

b) A network is said to be degree-assortative if nodes with similar degree are likely to interact with each other. Formulate a statistic to objectively quantify the degree assortativity of a given network. Dont forget to define the variables you use!

c) Using permutation tests, assess the statistical significance of the degree assortativity of the human PPI network by comparing the statistic you formulated in (b) in the original network vs. random networks with the same degree distribution. Explain and visualize your results. Is the human PPI network degree-assortative or disassortative?