Question
Please explain these results, specifically explain the meaning of the overall relative risk of 2.32 and why is significant. Seven randomized controlled trials (RCTs) reported
Please explain these results, specifically explain the meaning of the overall relative risk of 2.32 and why is significant.
Seven randomized controlled trials (RCTs) reported the outcome of achieving 5% weight loss in adults with overweight or obesity (Kuller et al 2012, Weinhold et al 2015, Huseinovic et al 2016, Siddiqui et al 2017, Johnson et al 2019, Ma et al 2019, Rollo et al 2020). All studies reported data that could be pooled in meta-analysis. Participants receiving nutrition and physical activity interventions had a relative risk (RR) (95% CI) of 2.32 (1.64, 3.29) (p Studies Estimate (95% C.I.) Ev/Trt Ev/Ctrl Johnson et al_In_Person 2019 Johnson et al_Vid_Conf 2019 LEVA in Real Life_Huseinovic et al 2016 MEDIM_Siddiqui et al 2017 RAINBOW_Ma et al 2019 Rollo et al 2020 Weinhold et al 2015 WOMAN_Kuller et al 2012 0.33 (0.04, 2.69) 2.00 (0.68, 5.85) 3.10 (1.82, 5.28) 10.08 (0.58, 175.41) 1.87 (1.23 2.84) 1.87 (0.19, 18.38) 18.00 (2.54, 127.37) 2.20 (1.62, 3.00) 1/10 6/10 33/47 5/35 51/182 2/15 18/34 91/216 3/10 3/10 12/53 0/32 27/180 1/14 1/34 44/230 Overall (I^2=35.57 % , P=0.14) 2.32 (1.64, 3.29) 207/549 91/563 0.04 0.08 0.21 0.41 20.69 41.37 82.74 175.41 083 207 4.14 827 Relative Risk (log scale) Studies Estimate (95% C.I.) Ev/Trt Ev/Ctrl Johnson et al_In_Person 2019 Johnson et al_Vid_Conf 2019 LEVA in Real Life_Huseinovic et al 2016 MEDIM_Siddiqui et al 2017 RAINBOW_Ma et al 2019 Rollo et al 2020 Weinhold et al 2015 WOMAN_Kuller et al 2012 0.33 (0.04, 2.69) 2.00 (0.68, 5.85) 3.10 (1.82, 5.28) 10.08 (0.58, 175.41) 1.87 (1.23 2.84) 1.87 (0.19, 18.38) 18.00 (2.54, 127.37) 2.20 (1.62, 3.00) 1/10 6/10 33/47 5/35 51/182 2/15 18/34 91/216 3/10 3/10 12/53 0/32 27/180 1/14 1/34 44/230 Overall (I^2=35.57 % , P=0.14) 2.32 (1.64, 3.29) 207/549 91/563 0.04 0.08 0.21 0.41 20.69 41.37 82.74 175.41 083 207 4.14 827 Relative Risk (log scale)
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