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Problem 5. The following transformations (otherwise known as protecting group hell) were reported in the synthesis of a complex cyclic peptide. Predict the product of
Problem 5. The following transformations (otherwise known as protecting group hell) were reported in the synthesis of a complex cyclic peptide. Predict the product of each step. 1. NH3,MeOH 2. BnBr,NaHCO3 3. HCl, dioxane 4. FmocCl, NaHCO3 5. TrOH,H2SO4,AcOH,Ac2O 6. TBSOTf, lutidine 7. H2,Pd/C What conditions would you use to selectively remove each of the three protecting groups in the product
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