Question 1

The enhancement of the solubility of poorly soluble pharmaceutical drugs employs a number of various techniques including physical and chemical modifications of the drug. Discuss ANY FIVE of the techniques outlined below.

(i) Particle size reduction

(ii) Salt formation

(iii) Crystal engineering

(iv) Water solubilising groups

(v) Solid dispersions

(vi) Prodrugs

(vii) Cryogenic techniques

(viii) Inclusion complex formation (Total 25 marks)