Question 4 1 pts ApoB is a protein that is part of low-density lipoprotein (LDL). LDL that contains a defective protein is unable to bind its hepatic cell receptor, resulting in hypercholesterolemia, which predisposes a patient to heart disease at an early age. A single nucleotide substitution changes one amino acid residue from arginine to glutamine. A partial ApoB gene sequence for the coding strand is shown below. Determine the complementary strand sequence and mRNA sequence. Select the correct reading frame. What are the first three amino acids of this ApoB protein? 5...CTGGCCGGCTCAATGGAGAGTCC....3 Adapted from Pratt & Cornely 3.56 met-ala-gly met-glu-ser met-ser-gly leu-ala-gly gly-leu-ser met-arg-glu Question 3 1 pts A transcription factor that binds a particular sequence of DNA to start the process of RNA transcription might use which of the following interactions for specific DNA-protein binding? hydrogen bonding in the major groove Watson-Crick-Franklin base pairing shape complementarity to a B-form helix hydrogen bonding to the 2'OH on the sugar hydrophobic effect glycosidic bonds Question 1 1 pts RNA has a ribose sugar and DNA has a deoxyribose sugar. The 2'OH in the ribose sugar changes which of the following properties of nucleic acid structure? the preferred sugar pucker conformation the glycosidic bond angle the phosphate-phosphate distance in the helix the width of the major groove in the helix whether the helix is A-form or B-form the dipole moment of the pyrimidine base Question 2 1 pts Which of the following enzymes use nucleotide base pairing for specificity and positioning of the substrate? ribosome DNA polymerase RNA polymerase 5 0 0 0 0 HIV reverse transcriptase DNAse RNAse