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Question 6. Imagine you want to deprotonate cyclohexanone in the most efficient way possible (i.e. with the highest conversion to products). Of the bases given,
Question 6. Imagine you want to deprotonate cyclohexanone in the most efficient way possible (i.e. with the highest conversion to products). Of the bases given, which one(s) would you choose? Why? (1 page, 4 marks) "Base" + H-Base cyclohexanone pka 24.8 Bases to choose from (pKa's given are of their corresponding conjugated acids, i.e. Base): KOH triethylamine (pka 10.8) lithium diisopropylamine (LDA, pka z 36) 4-dimethylaminopyridine (DMAP, pka z 9.2) butyllithium (Buli, pka - 60) potassium hydroxide pka 15.7
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