Refer to the case study and all the questions, all answers must be correct.

Business law, case study, 2017 Abhishekh holds the promissory note as a holder in due course. He gives it to Aishwarya. Is Aishwarya holder in due course why?

30 Why isn't the blood of polycythaemia vera patients, after repeated phlebotomies, used for transfusion purposes? Although it is a premalignant condition, the red cells do not contain a nucleus and thus transfusion of only pure red blood cells (RBCs) would be a great benefit.

31 What investigations are necessary to exclude secondary polycythaemia?

32 What is the management plan in a patient with secondary polycythaemia presenting with transient ischaemic attacks (TIA)?

33 Why do patients with polycythaemia vera have a tendency to bleed, even though 50% of them have an elevated platelet count?

34 In hyposplenic patients, what precautions are necessary for patients who intend to travel to Saudi Arabia for the Haj?

35 What is the mechanism of development of splenomegaly in chronic leukaemia?

36 In idiopathic thrombocytopenic purpura (ITP), thrombocytes are mainly destroyed in the spleen owing to an immune mechanism. Why, therefore, is there no splenic enlargement as there is with other diseases?

37 Where exactly is the Traub's space? How exact is the percussion of the Traub's space as a sign indicating the size of the spleen?

38 Can you please tell me the indications and complications of blood transfusion.

39 Several times I have read the phrase 'white blood cells elevated with a left shift'. I am wondering what 'left shift' or 'left deviation' stands for.

40 What is the clear definition of 'bleeding time' and 'clotting time'? And what are the applied differences between them?

41 What is the meaning of the international normalized ratio (INR) blood test?

42 What is the cause of moderate thrombocytopenia in Bernard-Soulier syndrome? It is a qualitative defect not a quantitative platelet disorder