Role of FAD as Electron Acceptor Acyl-CoA dehydrogenase uses enzyme-bound FAD as a pros- thetic group to dehydrogenate the a and 3 carbons of fatty acyl-CoA. What is the advantage of using FAD as an electron acceptor rather than NAD? Explain in terms of the standard reduction potentials for the Enz-FAD/FADH (E"=-0.219 V) and NAD*/NADH (E" = -0.320 V) half-reactions.