Statistical test used-Patients who received guideline-recommended therapy (BB AA ST) were set as the reference group for the analyses. First-stage treatment choice regressions were estimated individually for the remaining 7 drug combinations. These first-stage treatment-choice models were specified as a function of the instruments and all measured covariates. F-statistics were used to assess the correlation between the instruments and treatment choice in this first-stage model. For the second-stage model, study outcomes were regressed on the estimated treatment probabilities for each of the 7 drug combinations, along with the same set of measured covariates included in the first-stage model. All models were estimated with robust standard errors. The analytic dataset was created using SAS software (version 9.3; SAS Institute Inc.; Cary, NC, USA), and statistical analyses were performed with Stata (version 17; StataCorp LLC.; College Station, TX, USA). An Institutional Review Board approved this study